Objective To investigate the contamination status, serotype distribution, drug sensitivity and molecular epidemic characteristics of salmonella in poultry meat sold in Liaoning Province in 2022, and to explore the relationship between different serotypes and MLST and drug resistance. MethodsS The collected samples were tested and identified by biochemical experiment according to GB4789.4-2016 "National Standard for Food Safety Microbiology Inspection of Salmonella" test method, slide agglutination method was used for serological experiment, and micro-broth method was used for drug sensitivity test of strains. BioNumerics 7.6 software was used to analyze the results of drug sensitivity and multilocus sequence typing (MLST). ResultsSSThe 53 Salmonella strains contained 11 serotypes, mainly S. Enteritidis. In the drug sensitivity analysis, the resistance rate of Salmonella to nalidixic acid (NAL) was the highest, 92.5%(49/53), a total of 25 multiple drug resistance spectra were found, and the total resistance rate was 66.0% (35/53). In the drug resistance gene analysis, the tetracycline resistance gene tet(C) carried the highest rate of 45.3% (24/53). Salmonella was classified into 10 ST types and 1 unclassified type according to the sequence of 7 housekeeping genes. Conclusion The contamination rate of salmonella in poultry meat sold in Liaoning province is serious, the serotypes are diversified, the overall drug resistance level is high, and the situation of multiple drug resistance is serious. The standardized poultry breeding should be strengthened.