In years of blended teaching of Microbiology Experiment, we found that students' initiative is the key to the learning effect. In the past, some students were passive in spite of diverse teaching methods applied. In recent years, we have adopted the task-driven teaching method: responsibility system of team leader rotation, which has remarkably incentivized all the students. As a team leader, each student has played an important role in pre-class tasks, the implementation in class, and summarization after class. In addition, they actively cooperated with the team leader when not serving as the team leader. Finally, the proportion of students achieving excellent results in the course and the marks on the quality and ability were significantly improved. Moreover, this method has been recognized by the students.