[Background] Pseudomonas aeruginosa, one of the main pathogens causing clinical infections, is resistant to a variety of antimicrobial agents, which is difficult to be treated in clinical practice. Increasing attention has been attached to the research on the drug resistance of P. aeruginosa. [Objective] With the visualization function of CiteSpace, we explored the status, hotspots and trend of the research on the drug resistance of P. aeruginosa. [Methods] We performed a bibliometric analysis involving 8 996 articles about the drug resistance of P. aeruginosa, which were published in Web of Science, CNKI, and Wanfang Data from 2014 to 2021. CiteSpace was used to analyze the number of articles published, author cooperation network, cooperation network of affiliated countries and institutions, and literature co-citation. Furthermore, we used CiteSpace to perform journal analysis, keyword clustering, and burst detection, aiming to reveal the hotspots and trends of this research field. [Results] The growth rate of the articles published in English was higher than that in Chinese. China ranked second only to the United States and India in the number of articles, showing great contribution to research achievements in this field and strong academic influence. The articles published in both Chinese and English concerned nosocomial infections and carbapenem-resistant P. aeruginosa. The difference was that papers published in Chinese focused more on the clinical prevention and treatment of drug resistance of P. aeruginosa, while those published in English mainly involved the basic research of the drug resistance. [Conclusion] The research on drug resistance of P. aeruginosa at home and abroad pays the highest attention to the production and control of new drug-resistant bacteria and nosocomial infection, suggesting that the above research topic is the research hotspot and trend in this field.