In order to study the effect of Armillaria mellea beverage on mice organic function, the model of immunosuppression was produced by cyclophosphamide (CY) modeling method. The immune function was studied by feeding different doses of Armillaria drinks. Meanwhile the total number of bacteria, E. coli, Lactobacillus and Bifidobacterium was measured. And the effects of Armillaria drinks on intestinal microflora were analyzed. Finally the toxicity test of the drinks was detected. Results showed that Armillaria drinks could significantly enhanced immune function, including promoting the development of spleen and thymus, spleen and thymus index, promoting phagocytic activity of macrophages. Meanwhile it could also promote the growth of beneficial flora, improve the intestinal microbial flora environment. Armillaria drinks did not produce any toxic effects on mice. Armillaria drinks enhanced not only immune function but also bowel function, maintaining and promoting the health of the body.