As a result of knowledge transferring before the class based on the flipped classroom, students can internalize their knowledge by accomplishing various interactive activities in class. Recently, we practiced the knowledge transferring of Immunology before class on the platform of “Wanke001.com”, which ensured that students can complete the task of self-study before class with high quality. This paper mainly studies the design, implementation and evaluation of Immunology classroom activities. This “teacher-led, student-centered” teaching model not only develops students’ self-learning ability, but also realizes the transformation of educational objectives from the primary stage of memorization and understanding to the advanced stage of application, analysis, evaluation and creation.