Due to the diversities of matriculate qualities and learning objectives, the verification experiment method of the microbiological experiment teaching, dominated by the teacher, has been unable to meet the current demand of students’ learning. The training model of experiment skills and scientific research diathesis were carried out through the combination of in-class and extracurricular experiments based on rich digital resources and the micro-research projects. As a result, it showed that this model can significantly improve not only the microbiological experimental teaching effectiveness, but also the students’ capabilities of autonomous learning and identifying-solving problems.