Bacillus strains are safe for human and animal, of no environmental pollution, not easy to be resisted by plant pathogen, of strong stress resistance and helpful of promoting plant growth. Due to these advantages, Bacillus strains are important bacteria in bio-control of rice blast. The main bio-control mechanisms of Bacillus include competitive effect, antagonism and the induced disease-resistance. Bacillus strains can colonize in rice plant, produce antifungal active substance to inhibit growth of Magnaporthe oryzae, induce rice disease-resistance, promote rice plant growth and save the rice yield loss. Bacillus strains could be used as bio-control agents against rice blast in Southern and Northern regions of China. It has a guiding significance for the protection of rice blast in rice sustainable development. This article summarized the application progresses of Bacillus strains in bio-control of rice blast, the mechanism of Bacillus strains in bio-control of rice blast, influence factors of bio-control efficiency about Bacillus strains in bio-control of rice blast.