Three Yersinia species are pathogenic to rodent and human, include Yersinia pestis, Y. enterocolitica and Y. pseudotuberculosis. Y. pseudotuberculosis can transport across microfold cell (M cell) distributed on the peyers patch of small intestine of mouse. They initially take advantage of the surface docks such as adhesins YadA or invasin to interact with β1 chain of integrin receptors at the host cell surface. Then, Yops are exported by the type III secretion systems (TTSSs) when secretion channels open, and finally give rise to suppressed host immune response. Many studies about Y. pseudotuberculosis have been published over the past 30 years. Advances about molecular mechanism of interaction between Y. pseudotuberculosis and host cell have been reviewed here. Meanwhile, the focal point and developing trend about Y. pseudotuberculosis were also discussed.