The cultivation aim of Bio-engineering experiment teaching is to construct “bead-chain” mode. This paper shows some approaches in reforming experimental teaching. By optimization of experiment teaching contents, improving experiment teaching method and examination way, increasing comprehensive and designing experiments of project, constructing of the open laboratory and so on, good effect was achieved by the formation of an orderly “chain” of knowledge system of Bio-engineering. An innovative experimental teaching system of “bead-chain” is constructed which based on the microorganism producing amylase as a starting point and the experiment project for “bead” in the mode of genetic engineering, enzyme engineering, fermentation engineering. The experimental teaching system enables the students to have the ability of application, innovation and competitiveness of employment.