Infective endocarditis (IE) remains one of the major diseases, which poses a serious threat to human health. In recent years, human being is facing an increased incidence rate of IE and therefore accurate diagnosis and effective treatment as well as preventive measurements become urgent clinical and public health issues. This review?summaries the recent progress of IE in laboratory diagnosis, treatment, the risk factors and preventive measures concerning Bartonella species and BE, including 538 Bartonella endocarditis (BE) cases and their epidemiology. It is anticipated that associated studies have substantial significance on the understanding and control of BE of human being.