Fermentation Engineering is one of the most important practicality specialized course for undergraduates majoring in biological engineering specialty, and the teaching quality has critical effects on students’ professional ability for their practical work after graduated. For the purpose to improve the teaching efficiency and enhancing the practical experience on fermentation engineering, the teaching ideas, methods, and functional partition were explored and practiced. Based on the content, the course was divided into four unites including fermentation equipments, solid fermentation, liquid fermentation, and the products isolation. Based on the fermentation technology, the experiment course was practiced peculiarity with the whole procedure of wine fermentation in laboratory. And the technical training was accomplished in fermentation workshop. Based on the lecture module, the course was accomplished in classroom, laboratory, and workshop by professor of the university, professionally engineer of the industry, and laboratory technician. The stereoscopic teaching system consists of basic theory studies, operation exercises, and workshop engineering practices, were constructed and practiced for three years with more than 240 peoples. The results indicated that this was helpful for their social practice ability and enhance innovative competence.