Probiotics are defined as live microorganisms that, when administered in adequate amount can confer a health benefit on the host and regulate the immune system. Accumulated evidence has been demonstrated the alleviation of allergic symptoms by probiotics was conducted via regulation of Th1/Th2 balance as well as the improvement of oral tolerance of the hosts. In this paper, the research progresses in last decade in the anti-allergic effect of probiotics in vitro tests, in experimental animals as well as clinical trials are reviewed. It is shown probiotics is of great potentials in adjuvant treatment of allergic diseases.