Foot-and-mouth disease is a devastating disease of livestock that has had a significant impact on world economies and prevailed in many countries and areas throughout the world. Although the traditional inactivated vaccine is effective, there are a number of concerns with its use. So many researchers have attempted to develop new vaccines that may provide additional tools to help control FMD in future. In this paper, based on the research work in our lab, we reviewed the international research progress on the new-type vaccines of FMD including genetically engineered live-attenuated or inactivated vaccines, protein and synthetic peptide vaccines, empty capsid vaccines, and cytokine-enhanced vaccines.