A new teaching method was developed in the curriculum of Harmful Microorganisms Control Technology. It is characterized by students’ self-learning followed by student’s instruction. Both students and teacher have succeeded in this model after four stages of practice, in which a pleasant learning atmosphere was created in the classroom. An effective interaction between teacher and students was achieved. Students are viewed as main objects in the classroom and they are encouraged to ask questions, to formulate their own ideas, or to find things out for themselves. Thus, students’ abilities including presentation, communication, competition, and cooperation were enhanced. By adapting their role to the new teaching method, teachers have also improved their teaching skill and strategies.