Microbiology is an important, fundamental and obligatory course in contemporary life science. This article introduces that teaching group of microbiology in Nankai University realizes transformation of teaching center, fully embodies the modernization of teaching notion and gives full play to students′ main effect practically by adhering to teaching reform as center, optimizing teaching method as measure, communicating in and after class and using multi-media and teaching web. Therefore, teaching system is established to adapt to modern teaching notion and eventually microbiology course becomes a cultivation platform to foster elites with both solid fundamental theory and innovating mind.