Medical Microbiology is an important basic course for undergraduate students in medical colleges and universities. The Medical Microbiology course, launched by Shanghai Jiao Tong University School of Medicine, has been awarded the National Superfine Course in 2005. Since then, we have continued to push forward the teaching reform, through strengthening the construction of faculty team, exploration of new teaching methods, close combination with clinical resources and the introduction of diversified assessment criteria. These attempts may have significance to realize the training goal of talents with both knowledge and ability.