The time that industrial microbiology alone took the course is short, so it requires a discussion about reform on teaching content and method. The thesis first discusses the reforms on teaching content from basic theory knowledge combining to scientific research, experiment and producing practice. Then reforms the teaching method, such as adopting the computer-assisted instruction (CAI) pattern, combining the problem-based learning (PBL) and case-based studying (CBS) each other, and leading into partly bilingual education method. By all above investigation and discussion practice in two aspects, the students produces deep interest to industrial microbiology, and reached the purpose of teaching reform.