The course Bioremediation of Environmental Pollution, which plays a vital role in the professional training system, is a professional elective course for college students majored in environmental science, environmental engineering and agricultural resources and environment. In view of the problems identified in previous teaching experiences, the teachers carried out teaching reform to meet the demand for high-quality personnel training. The teaching reform included optimization of course objectives, reconstruction of course content and knowledge integration, reform and innovation of teaching methods. The practices indicate that a reformed curriculum teaching significantly improves the achievement of the teaching objectives. Moreover, it effectively enhances the students' independent learning, thinking and comprehensive knowledge application ability, achieving sound teaching effects.