基于壳聚糖的可控缓释型微针制备与性能评价
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Preparation and performance evaluation of controlled-release chitosan-based microneedles
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    摘要:

    在临床应用上,一种能够持续递送药物的微针(microneedle,MN)系统对于一些疫苗、激素类药物的递送具有重要价值。本文研究设计了一种基于壳聚糖的可控缓释型微针阵列(PVA/CS-MN),将微针贴片与药物相结合用于药物的可控长效缓释。重点研究了PVA/CS-MN的制备优化工艺,并对MN阵列外观形貌、力学性能、溶解与溶胀性能以及体外刺入性能进行了表征。实验结果表明,使用最优工艺制备的PVA/CS-MN具有良好的形貌以及力学性能,可以顺利在皮肤上打开微通道,并实现可控的溶解与溶胀功能。同时,体外透皮扩散实验表明,以抗坏血酸(l-ascorbic acid)为模型药物制备的Vc-PVA/CS-MN在1 h内即释放了约57%的药物,随后12 h内缓慢释放了约66.7%的药物,7 d后最终释放了92%的药物。PVA/CS-MN具备可控的缓释特性以及优良的药物递送效率,为药物的持续透皮递送提供了一个新选择。

    Abstract:

    In clinical application, a microneedle system that continuously delivers drugs is of great value for the delivery of some vaccines and hormone drugs. In this study, a controlled-release chitosan-based microneedle array (PVA/CS-MN) was designed, combining microneedle patches with drugs for controlled-release of drugs. Here we report the optimization of the preparation process of PVA/CS-MN. The appearance, morphology, mechanical properties, dissolution and swelling properties, and in vitro penetration properties of the MN arrays were characterized. The PVA/CS-MN prepared by the optimal process showed good morphology and mechanical properties. PVA/CS-MN can smoothly open microchannels on the skin and achieve controllable dissolution and swelling functions. Ascorbic acid (l-ascorbic acid) was used as a model drug to prepare a Vc-PVA/CS-MN. In vitro transdermal diffusion experiments showed that the Vc-PVA/CS-MN released about 57% of the drug within 1 h. About 66.7% of the drug was slowly released within 12 h, and a total of 92% of the drug was released after 7 days. The controllable sustained-release properties and excellent drug delivery efficiency of PVA/CS-MN provide a new option for sustained transdermal drug delivery.

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朱龙,庄俭,赵泽伟,刘俸溢,薛庆隆,孙靖尧,黄尧,许红. 基于壳聚糖的可控缓释型微针制备与性能评价[J]. 生物工程学报, 2022, 38(9): 3478-3488

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历史
  • 收稿日期:2022-04-08
  • 最后修改日期:
  • 录用日期:2022-05-24
  • 在线发布日期: 2022-09-24
  • 出版日期: 2022-09-25
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