Curriculum ideological and political education is a new teaching concept popularized widely in colleges and universities in China in recent years. Its core idea is to integrate ideological and political education into the teaching of various courses. University courses can be divided into ideological and political courses, general education courses, philosophy and social science courses, and natural science courses. Among them, natural science courses have the loosest relationship with ideological and political education, and thus the integration of ideological and political elements is the most difficult. In this study, based on the practice of integrating ideological and political education into the teaching of Microbiology courses, we analyzed the necessity and difficulties of implementing curriculum ideological and political education in natural science curriculum, explore the path of mining ideological and political resources, evaluated the teaching effectiveness through the investigation and research, and performed teaching reflection on the practice of curriculum education. In addition, we also discussed the differences of views on curriculum ideological and political education among teachers of specialized courses. This study aims to provide theoretical support, empirical data and teaching experience for Microbiology related courses to implement curriculum ideological and political education, and also serve as a reference for other natural science courses.