In mushroom cultivation industry, Trichoderma spp. not only pollutes the mushroom substrate but also infects mycelia and fruiting bodies causing a dramatic loss in economy. In this paper, the morphology characteristics and biochemistry basis of the interaction mechanism between Trichoderma spp. and edible fungi are summarized, the research advances of the disease resistance inheritance and mechanism on edible fungi are discussed, and the problems of the interaction mechanism between the host and pathogens that should be researched in the future are suggested.