Soil pesticide contamination and bacterial drug resistance are hotspots in the field of environmental study. In recent years, a growing number of studies have shown that the development of bacterial pesticide-antibiotic cross-resistance was related to soil pesticide contamination. Based on the research progress in recent years, the pollution status of pesticides including insecticides, herbicides, and fungicides in the soil at home and abroad were described in this paper. Pesticide degrading bacteria and their resistance to pesticide, and the problem of bacterial antibiotic resistance and pesticide-antibiotic cross-resistance were also introduced. Finally, research priorities in future studies on pesticide-antibiotic cross-resistance were prospected.