Flipped classroom, one of the most popular teaching modes in recent years, takes the students as the main body. QQ platform was used for Immunology flipped classroom and achieved a good effect. However, due to the QQ platform technical constraints, it is difficult for teachers to supervise and examine students’ self-study. Therefore, on the basis of our recent practice, “Wanke001.com” was used as a platform designed to complete the pre-class self-study tasks to get points as a pre-class teaching evaluation. Using “Wanke001.com” as a platform has proved that it not only promoted the students to complete pre-class self-study tasks in high quality, but also enable teachers to know how students understand the pre-class content timely, so that in-class teaching would be more targeted to improve the teaching effect of the immunology flipped classroom.