WSWXTB微生物学通报Microbiology China0253-2654微生物学通报编辑部中国北京wswxtb-48-11-424010.13344/j.microbiol.china.210041专论与综述Reviews猪流行性腹泻病毒诱导的猪肠道-乳腺-sIgA轴以及免疫机制探讨Gut-mammary-sIgA axis and immunologic mechanisms induced by porcine epidemic diarrhea virus陈冰清CHENBingqingΔ1葛艳GEYanΔ2司伏生SIFusheng1董世娟DONGShijuan1*李震LIZhen1*上海市农业科学院畜牧兽医研究所 上海市农业遗传育种重点实验室 上海市种猪育种工程中心 上海 201106Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences; Shanghai Municipal Key Laboratory of Agri-Genetic and Breeding; Shanghai Engineering Center of Pig Breeding, Shanghai 201106, China同济大学医学院 上海 200092Tongji University School of Medicine, Shanghai 200092, China
E-mail:董世娟:dsjnm@163.com
Swine gut-mammary gland-sIgA (secretory IgA) axis is an immune route involving pregnant sows, which, once being infected or vaccinated by a gastroenteric route with an enteric pathogen can confer immune protection to their offspring against such pathogen through IgA contained in their colostrum or milk. The dynamic model of the axis is composed of complicated processes (e.g., invasion of pathogen, antigen presentation, activation of lymphocytes, homing of lymphocytes into intestine or mammary gland, and antibody secretion), which may be influenced or regulated by various factors such as virulence of pathogen, stage of pregnancy, and immune state of sow. The study about the axis model evoked by infection of porcine epidemic diarrhea virus (PEDV) can be used to explain the immune protection acquired through infection of virulent virus, while the design of vaccine and vaccination protocol depending on the model has not been satisfactory. This review summarized the studies about PEDV infection and host immune response and analyzed the key factors influencing the axis. It is suggested that more attention should be paid to functions of inactivated PEDV vaccine and specific IgG antibody though the immune axis, which is the most efficient mechanism for PEDV prevention.
肠道-乳腺-sIgA轴猪流行性腹泻病毒动力模式IgGIgA细胞免疫体液免疫gut-mammary gland-sIgA axisporcine epidemic diarrhea virusdynamic modelIgGIgAcellular immunityhumoral immunity上海市科技兴农项目2020-02-08-00-12-F01478上海市科技兴农项目(2020-02-08-00-12-F01478)Shanghai Key Projects on Agricultural Development2020-02-08-00-12-F01478Shanghai Key Projects on Agricultural Development (2020-02-08-00-12-F01478)
Schematic of relative T and IgA+ B cell numbers and relative expression of chemokine CC receptor (CCR) 10 and chemokine CC ligand (CCL) 28 in the swine mammary gland during pregnancy and lactation (MG)[4]
Routes of PEDV vaccination and passive immunity by new born piglet
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