In order to ensure the teaching quality under the novel coronavirus pneumonia epidemic, the teaching team actively reformed the teaching of Industrial Microbiology course by restructuring the teaching system and teaching process design. On the basis of Superstar Fanya network teaching platform, an intelligent teaching system integrating network classrooms and digital resources was established, and the design and implementation of the teaching process of Industrial Microbiology was restructured. The online teaching assessment model was preliminarily explored, and the effectiveness of teaching reform was also evaluated. The practice indicated that the reformed curriculum teaching was helpful to stimulate students’ learning interest, improve self-learning ability, promote teacher-student interaction, and finally achieve good effects.