Fermentation engineering is one of the core courses in the field of bioengineering in colleges and universities of science and engineering. It is an applied and practical professional course, and the traditional application of this course has been unable to meet the current needs of college students looking for quality engineering education. With the rapid development of information technology and automatic control technology, multi-level and interdisciplinary “Internet Plus” teaching has become a new mode of talent training in higher education. In this paper, the fermentation engineering practice and virtual simulation pilot laboratory platform takes engineering as a technical means-combining VR technology, information automation control technology, and database and fermentation process controlling through “Internet Plus”; Constructing a “multi-dimensional” engineering laboratory pilot platform with the combination of “virtual reality”, and using it for innovation and exploration toward building quality education and teaching in the Food Fermentation Skills Training Course of fermentation engineering specialty. The results of the preliminary construction and the earlier teaching results show that the construction of the laboratory platform has a clear improvement in the practical ability of the fermentation engineering and related professional students, and has accumulated valuable experience and immeasurable engineering training data for later construction.