Based on the current multimedia classroom teaching, the paper introduces the mind map and proposes a new visual thinking strategy for the teaching of Microbiology in local teachers colleges. In this paper, six key teaching links, such as teaching design, introduction of new courses, blackboard design, class notes, review summary, and teaching evaluation, are applied in the teaching process of Microbiology. It is pointed out that mind mapping can not only improve the teaching effect of teachers. It can also improve students’ learning efficiency. At the same time, it is also a teaching method that can promote students’ enthusiasm and initiative, stimulate students’ association and creativity, form students’ systematic learning and thinking habits, and realize “student-centered” teaching methods.