[Background] Marine-derived fungi are prolific resources of natural products due to their diversity and ability to produce novel bioactive compounds. [Objective] To obtain the bioactive secondary metabolites from the fungus Parengyodontium album SCSIO 40430, which isolated from a Montipora foliosa sample from the South China Sea, and to evaluate for their antibacterial activity. [Methods] The compounds were isolated and purified by silica gel column, Sephadex LH-20 column and semi-prepartive HPLC chromatography. Their structures were identified by HR-ESI-MS, 1H, 13C NMR, and comparison with the data of literatures. [Results] Three compounds were isolated from the butanone extract and structurely identified as deoxyphomalone (1), 2-ethyl-3,5-dihydroxy-11-methylchroman- 9-one (2) and 2-ethyl-3-hydroxy-5-methoxy-11-methylchroman-9-one (3). [Conclusion] Three chromanone compounds were aquired, and compounds 2 displayed antibacterial activities of Methicillin-resistant Stphylococcus and Bacillus thuringiensis SCSIO BT01 (MIC 16 μg/mL).