Based on the training plan and employment direction of bioengineering specialty, course group has become an important approach to improve the specialty development. The fermentation course group contained two main courses, which were “Biotechnology” and “Bioreaction Engineering”, and three optional courses which were “Bioengineering Equipment”, “Bioprocess Monitoring and Control” and “Metabolic Control and Fermentation”. In addition, other practice teachings, such as “Fermentation Experiment”, “Production Practice” and “Graduation Design”, were also employed to constitute the course group. In this paper, the integration of teaching content in the group was introduced, and the teaching mode of combining classroom teaching with practice teaching was analyzed. The results indicated that the teaching reform of fermentation course group is helpful for students' employment and ability promotion of social practice and innovative competence.