| 海洋真菌杂色曲霉F62丁内酯类化合物研究 |
| Butyrolactone derivatives isolated from the marine fungus Aspergillus versicolor F62 |
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| 中文关键词:相似蜂海绵，杂色曲霉，次生代谢产物，丁内酯 |
| 英文关键词:Haliclona simulans, Aspergillus versicolor, secondary metabolites, butyrolactones |
| 基金项目:国家“十二五”科技重大专项“综合性新药研究开发技术大平台”（No. 2012ZX09301-002-001-005）；中央高校基本科研业务费（No. 2012N06） |
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| 中文摘要: |
| 为了深入研究相似蜂海绵相关真菌杂色曲霉F62的活性代谢产物，采用硅胶柱、凝胶柱色谱和HPLC等分离手段对其大米固体发酵物的乙酸乙酯提取物进行分离，并利用质谱和核磁共振等现代波谱学技术对其结构进行鉴定，从中共得到6个丁内酯类化合物，分别为丁内酯Ⅰ（1）、丁内酯Ⅱ （2）、丁内酯Ⅲ（3）、丁内酯Ⅳ（4）、丁内酯Ⅶ（5）、Aspernolides A（6），其中化合物1在10μmol/L时表现出较强的抗炎活性，其IC50值为8.73μmol/L。 |
| 英文摘要: |
| Chemical diversity investigation for searching novel bioactive compounds from secondary metabolites of the marine fungus Aspergillus versicolor F62 was carried out. Various modern separation methods and spectral techniques were employed for isolation and identification of target compounds. Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. Six butyrolactone derivatives were identified as butyrolactone Ⅰ (1), butyrolactone Ⅱ (2), butyrolactone Ⅲ (3), butyrolactone Ⅳ (4), butyrolactone Ⅶ (5), and Aspernolide A (6). Compound 1 exhibited moderate anti-inflammatory activity at the concentration of 10μmol/L and the IC50 value was 8.73μmol/L. |
| 巩婷,董世豪,朱平. 海洋真菌杂色曲霉F62丁内酯类化合物研究[J]. 菌物学报, 2014, 33(3): 706-712 |
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