| 色钉菇子实体化学成分及其生物活性初探 |
| Chemical constituents of fruiting bodies of Chroogomphus rutilus and their biological activities |
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| 中文关键词:核磁共振波谱，DPPH自由基，抗氧化，人胃癌细胞株BGC，抗肿瘤 |
| 英文关键词:nuclear magnetic resonance spectrum (NMR), 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), antioxidant, human gastric cancer cell line BGC, anti-tumor |
| 基金项目:河北省科技计划项目（No. 11230908D）；河北省教育厅重点项目（No. ZH2011231） |
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| 中文摘要: |
| 从色钉菇Chroogomphus rutilus子实体中分离纯化出11种化合物，经核磁等方法鉴定为：（1）麦角甾-7,22-二烯-3-酮；（2）麦角甾-4,6,8(14), 22-四烯-3-酮；（3）邻苯二甲酸二丁酯；（4）顺式-3-己烯醇；（5）3β,5α,6β-三羟基麦角甾-7,22-二烯；（6）α-甜没药醇；（7）2-甲氧基腺嘌呤核苷；（8）(4E,8E)-2-N-(2-羟基棕榈酰)-1-O-B-D-吡喃葡萄糖基-9-甲基-4, 8-sphingadienine；（9）5-羟基尿嘧啶核苷；（10）2-氨基-3-醛基-6-甲氧基吡啶；（11）Polyozellin。对分离化合物的体外抗氧化、抗肿瘤活性的初步测定结果显示，2-甲氧基腺嘌呤核苷、顺式-3-己烯醇表现出较强的清除DPPH自由基活性，EC50值分别为0.06128mg/mL和0.08253mg/mL。5-羟基尿嘧啶核苷对人胃癌细胞株BGC的增殖有较强的抑制作用，IC50值为7.92μg/mL。研究结果为进一步开发利用色钉菇提供了科学依据。 |
| 英文摘要: |
| Eleven compounds were isolated from fruiting bodies of Chroogomphus rutilus. They were identified as ergosta-7,22-dien-3-one (1), ergosta-7,22-dien-3-one (2), dibutyl phthalate (3), cis-3-hexenol (4), cerevisterol (5), α-bisabolol (6), 2-methoxyadcnosine (7), (2S,3R,4E,8E,2’R)-2-N-(2’-hydroxy-palmitoyl)-1-O-B-D-gluco-pyra-No-syl-9- methyl-4,8-sphingadienine (8), 5-hydroxyuridine (9), 2-amino-3-formyl-6-methoxypyridine (10), and polyozellin (11). The preliminary analysis of antioxidant and anti-tumor activities of the compounds indicated that 2-methoxyadcnosine and cis-3-hexenol revealed the higher capacity on scavenging DPPH free radical with EC50 value of 0.06128mg/mL and 0.08253mg/mL. Moreover, 5-hydroxyuridine could strongly inhibit the BGC cell line proliferation with IC50 value of 7.92μg/mL. These results provided scientific basis for the development and utilization of C. rutilus. |
| 冯建,秦淑亮,胡兵,赵晓静,王立安. 色钉菇子实体化学成分及其生物活性初探[J]. 菌物学报, 2014, 33(2): 355-364 |
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