| 黄白侧耳大米固体发酵次级代谢产物分析 |
| Isolation and identification of secondary metabolites from the solid culture of Pleurotus cornucopiae |
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| 中文关键词:黄白侧耳，苯酞，细胞毒活性，NO释放抑制活性 |
| 英文关键词:Pleurotus cornucopiae, phthalides, cytotoxic activity, NO inhibition |
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| 中文摘要: |
| 从黄白侧耳Pleurotus cornucopiae大米固体发酵物中分离得到4个苯酞类化合物，2个为新结构化合物：2-(ethoxymethyl)-3,5-diethoxybenzyl acetate（1）、2-(acetoxymethyl)-4,6-dimethoxybenzyl tridecanoate（2），2个为已知化合物：5,7-dimethoxyisobenzofuran-1(3H)-one（3）、4,6-dimethoxyisobenzofuran-1(3H)-one（4）。对化合物进行生物活性评价发现，化合物3、4具有抑制肿瘤细胞HeLa生长活性，IC50值分别为66.2和65.7μmol/L；化合物3和4对LPS诱导的RAW264.7细胞释放NO有抑制作用，IC50值分别为17.2和67.9μmol/L。 |
| 英文摘要: |
| Two novel natural products, 2-(ethoxymethyl)-3,5-dimethoxybenzyl acetate (1), 2-(acetoxymethyl)-4, 6-dimethoxybenzyl tridecanoate (2), and two known compounds, 5,7-dimethoxyisobenzofuran-1(3H)-one (3), 4,6-dimethoxyisobenzofuran-1(3H)-one (4) were isolated from the solid culture of Pleurotus cornucopiae. Compounds 3 and 4 showed moderate cytotoxicity against HeLa cell line with the IC50 values of 66.2 and 65.7μmol/L, respectively. Compounds 3 and 4 inhibited NO production in LPS-activated murine macrophage RAW264.7 cells with the IC50 values of 17.2 and 67.9μmol/L, respectively. |
| 王少娟,王雅琪,宝丽,杨晓莉,文华安,刘宏伟. 黄白侧耳大米固体发酵次级代谢产物分析[J]. 菌物学报, 2013, 32(6): 1028-1033 |
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