| 源于一株青霉菌的4,5-环氧环己烯类次生代谢产物研究 |
| 4,5-epoxycyclohexenoid derivatives from the fungus Penicillium sp. |
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| 中文关键词:Penicillium sp.，4,5-环氧环己烯类化合物，结构鉴定，细胞毒活性 |
| 英文关键词:Penicillium sp., 4,5-epoxycyclohexenoids, structure elucidation, cytotoxicity |
| 基金项目:国家自然科学基金（No. 30925039）；北京自然科学基金（No. 5111003） |
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| 中文摘要: |
| 从一株青霉菌Penicillium sp.（XZ075）的发酵粗提物中分离了4个4,5-环氧环己烯类新结构次生代谢产物penoxides A－D（1－4）和同类型的已知化合物eupenoxide（5），并采用质谱和核磁共振技术确定了新化合物的结构。化合物1的绝对构型是通过与已知化合物5比对核磁数据确定的，而2－4的绝对构型是通过与化合物1比对CD谱图确定的。活性测试结果表明化合物1，2及4对宫颈癌细胞（HeLa）具有中等的细胞毒活性。 |
| 英文摘要: |
| Four new 4,5-epoxycyclohexenoids, penoxides A－D (1－4), and a known analogue, eupenoxide (5), have been isolated from the crude extract of Penicillium sp. The structures of 1－4 were elucidated primarily by mass spectrum (MS) and nuclear magnetic resonance (NMR) techniques. The absolute configuration of 1 was deduced by comparison of its NMR data with those of 5, whereas those of 2－4 were deduced by comparison of their CD spectra with that of 1. Compounds 1, 2 and 4 showed modest cytotoxicity against HeLa cells. |
| 文浩,李彦,刘杏忠,高昊,姚新生. 源于一株青霉菌的4,5-环氧环己烯类次生代谢产物研究[J]. 菌物学报, 2012, 31(2): 267-274 |
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