| 尖顶羊肚菌对急性酒精性胃黏膜损伤保护作用研究 |
| The gastric protective effects of Morchella conica on the ethanol- induced gastric mucosal lesion in rats |
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| 中文关键词:尖顶羊肚菌，胃黏膜损伤，超氧化物歧化酶（SOD），丙二醛（MDA），谷胱甘肽（GSH），胃蛋白酶 |
| 英文关键词:Morchella conia, gastric mucosal injury, superoxide dismutase, malonaldehyde, glutathione, pepsin |
| 基金项目:国家产业技术体系专项：药用菌的栽培；四川省平台项目：四川重要名贵食用菌菌种资源信息档案库建设；国家现代农业产业技术体系：四川食用菌创新团队精深加工研究岗位[No. 川农业2009（75）] |
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| 中文摘要: |
| 研究尖顶羊肚菌菌丝体水提液对酒精引起的大鼠急性胃黏膜损伤的保护作用。以95%乙醇诱导的大鼠胃黏膜损伤为模型，测定各组胃黏膜损伤指数，并测定胃黏膜超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽（GSH）含量，采用幽门结扎法，测定大鼠胃酸、胃蛋白酶与胃黏液分泌的量。结果表明羊肚菌中、高剂量能明显降低胃黏膜损伤指数（p＜0.05）；羊肚菌不能抑制胃酸的分泌（p＞0.05），但是能增加胃蛋白酶与胃黏液的分泌（p＜0.05）；95%乙醇能引起胃黏膜SOD活性与GSH的降低，MDA含量的增加，给予羊肚菌能明显抑制这一现象。结果说明羊肚菌对急性酒精性胃黏膜损伤的保护作用是与增加胃黏液分泌与提高机体抗氧化能力有关。 |
| 英文摘要: |
| The effects of Morchella conica mycelial extract on the ethanol-induced gastric mucosal lesion of rats in vivo were investigated. The gastric mucosal lesion was induced by 95% ethanol, the lesion index was measured and the superoxide dismutase (SOD), malonaldehyde (MDA), glutathione (GSH) content in the gastric issues were tested. The gastric acid, pepsin and gastric mucus were detected in ligated pyloru rats. The result showed that the middle dose and high dose of M. conica mycelial extract could reduce the lesion index of gastric mucosal (p<0.05); M. conica did not inhibit the gastric secretion (p>0.05) but promoted the pepsin and gastric mucus secretion (p<0.05); The SOD activity and the GSH content were reduced, and the MDA content was increased after the rats were gavages by 95% ethanol, but these situations were reversed in M. conica treated groups. These results indicated that protective effects of M. conica against the ethanol induced gastric lesions were related to its effects of promoting gastric mucus and improving the antioxidant activity. |
| 罗霞,魏巍,余梦瑶,江南,许晓燕,郑林用. 尖顶羊肚菌对急性酒精性胃黏膜损伤保护作用研究[J]. 菌物学报, 2011, 30(2): 319-324 |
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