| 内生真菌产紫杉醇研究的回顾与展望 |
| Recent research advances on endophytic fungi producing taxol |
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| 中文关键词:紫杉醇，内生真菌，生物多样性，发酵工程 |
| 英文关键词:taxol, endophytic fungi, biodiversity, fermentation engineering |
| 基金项目:贵州大学创新基金[红豆杉产紫杉醇及其类似物内生真菌的研究（校研农2010006）] |
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| 中文摘要: |
| 紫杉醇是一种高效、低毒、广谱的天然抗癌药物，是人类未来20年间最有效的抗癌药物之一。近年来的研究发现，从植物内生真菌中发酵生产紫杉醇被证明是解决药源问题的有效途径。本文概述了微生物发酵生产紫杉醇的研究进展，包括产紫杉醇内生真菌的分离、多样性和真菌产紫杉醇的优势，紫杉醇的提取和检测技术，同时对如何提高内生真菌紫杉醇产量进行了比较全面的综述。随着现代分子生物学技术和微生物发酵工程的发展，工业上大规模发酵生产紫杉醇将有望实现。 |
| 英文摘要: |
| Taxol with high efficiency, low toxicity and broad-spectrum is one of the most effective natural anti-cancer drugs for the coming 20 years. Recent studies have found that taxol from the fermentation of endophytic fungi of plants has been demonstrated a high potential for efficient production of taxol. Summarize recent research advances in the technique of fermentation producing taxol including biodiversity of taxol-producing endophytic fungi, isolation of the fungi, and the techniques of taxol extraction. The pathways to improve the production of taxol by endophytic fungal were also comprehensively discussed. Along with the development of molecular biology techniques and fermentation engineering, the large-scale fermentation to produce taxol is hopefully realizable. |
| 康冀川,靳瑞,文庭池,何劲,雷邦星. 内生真菌产紫杉醇研究的回顾与展望[J]. 菌物学报, 2011, 30(2): 168-179 |
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