| 黑根霉对人参皂苷Re的生物转化 |
| Ginsenoside Re biotransformed by Rhizopus sp. |
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| 中文关键词:人参皂苷Re，发酵产物，高效液相色谱 |
| 英文关键词:ginsenoside Re, fermentation products, HPLC analysis |
| 基金项目:人参皂苷RG3、RG5、RK1益智作用机理的研究（No. 212-00026） |
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| 中文摘要: |
| 利用菌种黑根霉Rhizopus sp.对人参皂苷Re进行生物转化，并对人参皂苷Re及其发酵产物进行HPLC系统分析比较，经液相色谱-质谱分析得出人参皂苷Re转化率为92.16%，并制备出人参皂苷Re发酵产物中峰值升高的成分，转化后的人参皂苷发酵产物中化合物1确定为人参皂苷Rg2，化合物2为Rg2的同分异构体，得率为10.13%；化合物3和化合物4确定为人参皂苷Rg5/Rk1，得率为29.23%。从结果初步推测得出人参皂苷Re被黑根霉转化为人参皂苷Rg2的机理，人参皂苷Re转化成人参皂苷Rg5/Rk1的机理还有待于进一步研究。 |
| 英文摘要: |
| Ginsenoside Re was transformed by Rhizopus sp., and Re fermentation products were compared by HPLC system analysis. Liquid chromatography (LC) and mass spectrum (MS) analysis showed the conversion ratio of ginsenoside Re was 92.16%. The raised compound 1 in the panaxatriol fermentation products was identified as ginsenoside Rg2 with yield of 10.13%, while compound 2 and compound 3 respectively as ginsenoside Rg3 and Rk1 with yield of 29.23%. The results showed that Re can be biotransformated by Rhizopus sp. It was inferred that ginsenoside Re had been biotransformed into ginsenoside Rg2. The transformation of ginsenoside Re into Rg5/Rk1 needs further studies. |
| 包海鹰,李磊,昝立峰,王春玲,苏日古格. 黑根霉对人参皂苷Re的生物转化[J]. 菌物学报, 2010, 29(4): 548-554 |
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