| 灵芝发酵液酸性醇提物抗慢性支气管炎疗效的研究 |
| Investigation of the effects of acidic extracts from Ganoderma lucidum fermentation broth on chronic bronchitis |
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| 中文关键词:药用真菌，镇咳，祛痰，小鼠，药效 |
| 英文关键词:medicinal mushroom, expectorant effect, anti-tussive effect, mice, pharmacodynamics |
| 基金项目:安徽工程科技学院引进人才科研启动基金（No. 2007YQQ007）；农业部茶叶生物化学与生物技术重点实验室开放基金（No. LTBB200703010） |
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| 中文摘要: |
| 通过灵芝发酵液酸性醇提物对小鼠的镇咳、祛痰实验，及烟熏小鼠肺部组织的形态学观察，研究灵芝酸性醇提物抗慢性支气管炎的疗效。灵芝发酵全液，不同剂量的灵芝酸乙醇提取物、灵芝酸正丁醇提取物均能显著延长二氧化硫诱发的小鼠咳嗽潜伏期，并显著抑制小鼠咳嗽次数，有明显的镇咳作用。60mg/kg给药量的正丁醇提取物使小鼠气道酚红排泄量较对照组提高了50.7%，祛痰疗效也明显优于双黄连口服液。肺组织切片病理检查表明，灵芝酸性提取物明显减轻烟熏小鼠的气管、支气管粘膜损伤，慢性支气管炎的组织病理学变化明显轻于单纯烟熏模型组，且抗炎、抗损伤作用与双黄连相当，这可为灵芝酸产品的研究开发提供一定的药理依据。 |
| 英文摘要: |
| The effects of acidic extracts from Ganoderma lucidum fermentation broth on chronic bronchitis in mice were investigated by expectorant, anti-tussive experiments and morphological observations. Ganoderma lucidum fermentation broth (GFB), different dosages of ethanol-extracts and butanol-extracts of GFB significantly prolonged the latent period of cough induced by SO2 and reduced the frequency of coughing, exhibiting obvious expectorant effect. Butanol-extracts with a dosage of 60mg/kg improved the excretion of phenol red by 50.7% as compared with controls, showing distinct antitussive effect over Honeysuckle-Scutellaria-Forsythia extract mixture oral liquid oral liquid. Ganoderic acidic extracts obviously alleviated the bronchial trauma of smoked mice, and the pathomorphological change was noticeably decreased as compared with the model group. However, the anti-inflammatory and anti-injury effects were equivalent to Honeysuckle-Scutellaria-Forsythia extract mixture oral liquid, which may provide the pharmacological basis for the development of Ganoderic acidic products. |
| 赵世光 王林. 灵芝发酵液酸性醇提物抗慢性支气管炎疗效的研究[J]. 菌物学报, 2009, 28(6): 832-837 |
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