| 灵芝多糖对顺铂引起的呕吐具抑制作用 |
| Inhibitory effects of Ganoderma lucidum polysaccharides on cisplatin-induced vomit |
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| 中文关键词:5-HT3受体拮抗剂，恶心呕吐，异食癖，Fos蛋白表达水平 |
| 英文关键词:5-HT3 receptor antagonist, nausea/vomiting, pica, Fos protein expression |
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| 中文摘要: |
| 以雄性昆明小鼠为实验材料，研究灵芝多糖对顺铂引起呕吐的抑制作用。实验分为5组，生理盐水 + 生理盐水组：腹腔注射0.9% NaCl两次，格拉司琼 + 顺铂组：腹腔注射格拉司琼和顺铂，生理盐水 + 顺铂组：腹腔注射0.9% NaCl和顺铂，灵芝多糖 + 生理盐水组：腹腔注射灵芝多糖和0.9% NaCl，灵芝多糖 + 顺铂组：腹腔注射灵芝多糖和顺铂，两种成分的注射间隔为30min。上述处理每天1次，连续5d，比较各组小鼠对高岭土的摄取量和脑内Fos蛋白表达水平。结果显示：顺铂可增加小鼠高岭土摄取量和脑内Fos蛋白表达水平，而格拉司琼和灵芝多糖可减少小鼠对高岭土的摄取量并降低脑内Fos蛋白表达水平。因此认为灵芝多糖可有效抑制顺铂引起的恶心呕吐。 |
| 英文摘要: |
| In order to investigate inhibitory effect of Ganoderma lucidum polysaccharides on cisplatin-induced vomit, male KM mice used as test animal, and they were divided into 5 treatment groups, normal saline + normal saline treatment group, granisetron + cisplatin treatment group, normal saline + cisplatin treatment group, Ganoderma lucidum polysaccharides + normal saline treatment group, and Ganoderma lucidum polysaccharides + cisplatin treatment group. The mice of 5 groups were injected intraperitoneally with first agent followed by intraperitoneal injection of second agent 30min later. These treatments were conducted once a day and lasted for 5 days. Kaolin intake and brain Fos protein expression were assayed for the evaluation of anti-vomit effect. Results showed that granisetron or Ganoderma lucidum polysaccharides reduced the enhanced intake of kaolin and Fos expression in brain induced by cisplatin. It was suggested that Ganoderma lucidum polysaccharides possess inhibitory effects on cisplatin-induced vomit. |
| 颜艳 白文忠 王立安 裴林 杨洁 马永青 李华光. 灵芝多糖对顺铂引起的呕吐具抑制作用[J]. 菌物学报, 2009, 28(3): 456-462 |
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