| 灭蚊真菌贵阳腐霉Pythium guiyangense对大鼠的长期安全性测试 |
| A long-term test on the safety of Pythium guiyangense to rats |
| 投稿时间：2006-12-22 修订日期：2007-04-10 |
| 中文关键词:灭蚊真菌，贵阳腐霉，安全性 |
| 英文关键词:mosquito-killing fungus, Pythium guiyangense, safety tests |
| 基金项目:国家自然科学基金（No.30160003） |
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| 中文摘要: |
| 为了解灭蚊真菌贵阳腐霉Pythium guiyangense对大鼠是否有长期毒性作用。将大鼠120只随机分4组，经饮水口服贵阳腐霉菌丝体。菌丝剂量分别为200mg/kg、100mg/kg、50mg/kg，对照组饮自来水。分别于试验期的90d和180d各组取鼠总数的1/3处死进行检查，剩余1/3大鼠待停用菌丝体悬液2周后处死。观察大鼠一般情况、血常规、肝肾功能等各项生化和组织学指标。结果表明各组大鼠均发育正常，精神食欲好，体重增加；血液学、生化指标变化无明显的剂量-效应关系；内脏系数无异常；对重要脏器的解剖学及组织学检查未见明显异常。本研究结果证明灭蚊真菌贵阳腐霉对大鼠是安全的，从而为其在防治蚊虫的推广应用中的安全性提供了重要的毒理学依据。 |
| 英文摘要: |
| The present study is aimed at investigating if there possibly exist toxic effects of Pythium guiyangense, a mosquito-killing fungus isolated in Guiyang, China in 1994, on rats. 120 rats were treated for 90 and 180 days respectively with suspension of P. guiyangense mycelia orally, and the observation items involved growth index, biochemical and pathological changes of the body. Biochemical indexes including blood routine test and liver and kidney function tests. The results showed that the rats developed and gained their weight normally. The counts of their blood cells were within normal limits. No abnormality was found in biochemical or pathological examinations. It is concluded that P. guiyangense does not show pathogenicity to rats. The experiments were designed strictly following the national regulations for drug tests. The research results have given us confidence that P. guiyangense should be a safe agent for mosquito biocontrol. |
| 刘萍,苏晓庆. 灭蚊真菌贵阳腐霉Pythium guiyangense对大鼠的长期安全性测试[J]. 菌物学报, 2007, 26(3): 440-447 |
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