微生物学通报  2015, Vol. 42 Issue (8): 1618-1618

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金城
JIN Cheng
O 抗原分型与毒力的相关性分析
Correlation of O-antigen withvirulence
微生物学通报, 2015, 42(8): 1618-1618
Microbiology China, 2015, 42(8): 1618-1618
10.13344/j.microbiol.china.158008
O 抗原分型与毒力的相关性分析
金城    
《微生物学通报》编委会北京 100101
关键词: 脂多糖核心型    毒力基因    分布    
Correlation of O-antigen withvirulence
JIN Cheng     
The Editorial Board of Microbiology China, Beijing 100101, China
Key words: LPS core    Virulence genes    Distribution    

LPS由类脂A、核心多糖(分为外核心和内核心)和O抗原三部分组成[1],依据O抗原的外核心多糖的差异,大肠杆菌(Escherichiacoli) LPS被分为5种类型,分别为R1、R2、R3、R4、K12[2, 3, 4],并且外核心多糖的差异与大肠杆菌的致病性等生物学特性有关联[5, 6, 7]。因此,对LPS核心型的研究成为研究大肠杆菌致病性以及新型疫苗的新方向。

禽致病性大肠杆菌(Avian Pathogenic Escherichiacoli,APEC)可引起鸡、鸭及其他禽类的肠道外疾病,严重制约养禽业的健康发展,同时对食品安全构成威胁。因此开展对APEC的监测和研究,具有重要的经济及社会意义。本期介绍了张宇曦、祁克宗、于圣青等发表的论文“禽致病性大肠杆菌脂多糖核心型分布与毒力基因的相关性分析”[8],作者对分离自我国部分地区的APEC菌株的LPS核心型进行了检测,并分析了LPS核心型的分布及与毒力因子的相关性,证实了R1型为APEC主要的LPS核心型。

该论文将LPS核心型的分布及与毒力因子的相关性分析引入对APEC的研究,符合国际发展趋势,如能进一步扩大检测菌株的分布地区和样本量,并深入研究脂多糖核心型与APEC致病性的相关性,将为APEC核心型疫苗的研制和该病的防控提供重要依据。

参考文献
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[7] Dissanayake DRA, Wijewardana TG, Gunawardena GA, et al. Distribution of lipopolysaccharide core types among avian pathogenic Escherichia coli in relation to the major phylogenetic groups[J]. Veterinary Microbiology, 2008, 132(3/4): 355-363
[8] Zhang YX, Qi KZ, Yu SQ, et al. Distribution of lipopolysaccharide core type in avian pathogenic Escherichiacoli and its correlation with virulence gene[J]. Microbiology China, 2015, 42(8): 1619-1625 (in Chinese) 张宇曦, 祁克宗, 于圣青, 等. 禽致病性大肠杆菌脂多糖核心型分布与毒力基因的相关性分析[J]. 微生物学通报, 2015, 42(8): 1619-1625