细菌自然转化的机制及影响因素
Mechanism and influencing factors of natural transformation in bacteria
投稿时间:2018-01-04  
DOI:  10.13345/j.cjb.180005
中文关键词:自然感受态,自然转化,Ⅳ型菌毛,耐药基因
英文关键词:natural competence, natural transformation, type Ⅳ pilus, antibiotic resistant genes
基金项目:国家重点基础研究发展计划 (973计划) (No. 2015CB554202) 资助。
作者单位E-mail
宁年智 军事科学院军事医学研究院 微生物流行病研究所 病原微生物生物安全国家重点实验室北京 100071  
王慧 军事科学院军事医学研究院 微生物流行病研究所 病原微生物生物安全国家重点实验室北京 100071 geno0109@vip.sina.com 
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中文摘要:
      水平基因转移对耐药基因传播、编码毒素基因质粒的扩散和毒力岛的转移等过程具有重要的生物学意义。自然转化是指具有感受态的细菌从外界摄取并整合裸露DNA,是水平基因转移的方式之一。细菌发生自然转化极大地促进了耐药基因在不同细菌间的播散,导致细菌对抗生素耐药,给临床治疗带来极大的困难。许多细菌具备自然转化能力,但不同细菌自然转化过程存在着差异。细菌自然感受及转化的诱发及效率亦受到多种因素的影响。文中着重于阐述不同细菌的自然转化机制及其影响因素。
英文摘要:
      Horizontal gene transfer contributes to the spread of antibiotic-resistance cassettes, the distribution of toxin-encoding phages and the transfer of pathogenicity islands. Natural transformation, which is the process of competent cells to uptake free DNA from environment and to recombine this DNA into the chromosome, is a mode of horizontal gene transfer. Natural transformation promotes the spread of antibiotic-resistance cassettes among different bacteria, resulting in the emergence of antibiotic resistant bacteria. The emergence of antibiotic resistant pathogens poses an enormous threat to the treatment of infections. Natural transformation could occur in many bacteria, but the mechanism many be different in different bacteria. Also, the inducer and efficiency of natural transformation in different bacteria are influenced by various factors. This review focuses on the mechanism and influencing factors of natural transformation in bacteria.
宁年智,王慧.细菌自然转化的机制及影响因素[J].生物工程学报,2018,34(8):1297~1305
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