铜绿假单胞菌铁摄取与生物被膜形成研究进展
Iron uptake and biofilm formation in Pseudomonas aeruginosa
投稿时间:2017-04-05  
DOI:  10.13345/j.cjb.170140
中文关键词:铜绿假单胞菌,生物被膜,铁摄取,群体感应,调控因子
英文关键词:Pseudomonas aeruginosa, biofilm, iron uptake, qurom sensing, regulation factor
基金项目:国家重点基础研究发展计划 (973计划) (No. 2014CB846002),国家自然科学基金 (No. 31570126) 资助。
作者单位E-mail
于珊 1中国科学院生物物理研究所北京 100101  
马旅雁 2中国科学院微生物研究所北京 100101 luyanma27@im.ac.cn 
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中文摘要:
      生物被膜是单细胞微生物通过其分泌的胞外多聚基质粘附于介质表面并将其自身包绕其中而成的膜样微生物细胞聚集物。生物被膜的形成使细菌具有更强的适应外界环境的能力,也是导致微生物产生耐药性及慢性感染性疾病难以治疗的重要原因之一。铜绿假单胞菌在肺部的定殖是肺囊性纤维化病患者发病和死亡主要原因,其造成的感染通常与形成抗生素抗性极强的生物被膜有关。铜绿假单胞菌生物被膜的形成受控于多种复杂的细菌调控体系之下,包括群体感应系统及参与调节胞外多聚基质合成的双组分调控系统等。此外,为了利用低浓度的环境铁来维持生存并完成各种生理功能,铜绿假单胞菌进化出了一系列铁摄取系统,这些系统对其毒力因子的释放和生物被膜的形成又起着重要的调控作用。本文主要对铜绿假单胞菌生物被膜的形成与调控机制及其铁摄取系统进行了综述,为进一步了解及清除铜绿假单胞菌引发的问题提供途径与思路。
英文摘要:
      Biofilms are surface-associated communities of microorganisms embedded within self-secreted extracellular polymeric substances, and a major cause of chronic and persistent infections. Respiratory Pseudomona aeruginosa infection is the leading reason for morbidity and mortality in cystic fibrosis patients. The formation of biofilms by P. aeruginosa in the airway is thought to increase persistence and antibiotic resistance during infection. Biofilm formation of P. aeruginosa is regulated by complicated signaling systems including quorum sensing and two-component systems that control the synthesis of extracellular polymeric substances. Furthermore, iron is an essential and scarce nutrient for bacteria and an important signal factor. P. aeruginosa has developed multiple iron uptake systems to sequester enough iron for its survival, with important regulatory roles in both release of virulence factors and formation of biofilms. In this review, we summarize recent advances in biofilm formation and its regulation along with the iron-uptake strategies in P. aeruginosa, to provide new insights and understanding to fight bacterial biofilms.
于珊,马旅雁.铜绿假单胞菌铁摄取与生物被膜形成研究进展[J].生物工程学报,2017,33(9):1489~1512
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