腈转化酶在精细化学品生产中的应用
Applications of nitrile converting enzymes in the production of fine chemicals
投稿时间:2009-09-27  
DOI:  
中文关键词:腈水合酶, 腈水解酶, 酰胺酶, 腈转化酶, 生物催化, 精细化学品
英文关键词:nitrilase, nitrile hydratase, amidase, nitrile converting enzymes, biocatalysis, fine chemicals
基金项目:国家高科技研究发展计划(863计划)( No. 2009AA02Z203), 国家重点基础研究发展计划(973计划)(No. 2009CB724704), 浙江省自然科学重点基金(No. Z4090612)资助。
作者单位E-mail
郑裕国 浙江工业大学生物工程研究所, 杭州 310014 Zhengyg@zjut.edu.cn 
薛亚平 浙江工业大学生物工程研究所, 杭州 310014  
柳志强 浙江工业大学生物工程研究所, 杭州 310014  
郑仁朝 浙江工业大学生物工程研究所, 杭州 310014  
沈寅初 浙江工业大学生物工程研究所, 杭州 310014  
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中文摘要:
      腈化合物是一类重要的用于合成多种精细化学品的化合物, 它们容易制备, 并且可以合成多种化合物。传统化学水解方法将腈化合物转化为相应的羧酸或酰胺通常需要高温、强酸、强碱等相对苛刻的条件, 腈转化酶(腈水解酶、腈水合酶和酰胺酶)由于其生物催化过程具有高效、高选择性、条件温和等特点, 在精细化学品的合成中越来越受到人们的关注。许多腈转化酶已经被开发出来并用于精细化学品的生产。以下介绍了腈转化酶在医药及中间体、农药及中间体、食品与饲料添加剂等精细化学品生产中的应用。随着研究的不断深入, 将会有更多的腈转化酶被开发出来并用于精细化学品的生产。
英文摘要:
      Nitriles are an important type of synthetic intermediates in the production of fine chemicals because of their easy preparations and versatile transformations. The traditional chemical conversion of nitriles to carboxylic acids and amides is feasible but it requires relatively harsh conditions of heat, acid or alkali. Nitrile converting enzymes (nitrilase, nitrile hydratase and amidase) which are used as biocatalyst for the production of fine chemicals have attracted substantial interest because of their ability to convert readily available nitriles into the corresponding higher value amides or acids under mild conditions with excellent chemo-, regio- and stereo-selectivities. Many nitrile converting enzymes have been explored and widely used for the production of fine chemicals. In this paper, various examples of biocatalytic synthesis of pharmaceuticals and their intermediates, agrochemicals and their intermediates, food and feed additives, and other fine chemicals are presented. In the near future, an increasing number of novel nitrile converting enzymes will be screened and their potential in the production of useful fine chemicals will be further exploited.
郑裕国,薛亚平,柳志强,郑仁朝,沈寅初.腈转化酶在精细化学品生产中的应用[J].生物工程学报,2009,25(12):1795~1807
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