Estrogens are major substances of environmental endocrine disruptors, and biodegradation is the most economical, greenest and most suitable method to remove them. We elaborated the research status and progress of estrogen biodegradation by analyzing the major sources and hazards of estrogen, the isolation and identification of estrogen-degrading bacteria, the expression and detection of steroidal estrogen-degrading enzymes, the genomics study of estrogen-degrading bacteria and the estrogen degradation pathways. We also address future works of biodegradation of environmental estrogens.