Abstract:The regulatory mechanism of bacterial cell division has long been a research focus．Forming a septum at the middle of the cell，the seemingly simple process is involved by multiple regulation factors． Zring (FtsZ ring) is the skeleton of the splitting complex．The locus where Z ring is formed is not only the position the septum formed but also determines the cell division site． Formation ofZring in the incorrect location results in inequality cell division． Several cell division regulation systems have been identified，including the Min system，nucleoid occlusion and the MipZ protein which effectively prevent Zring assembly by different mechanisms，ensuring formation of the fission complex at the correct position． Recent progresses about the formation process of Zring and regulation mechanism affecting the Z-ring positioning are summarized．